解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The resting and reflex-evoked activities of single postganglionic sympathetic neurons with axons in the right thoracic vagus were tested in chloralose-anaesthetized cats. The properties of a majority of neurons were found to be similar. Cardiac- and inspiration-related rhythmicities were present in the resting activit...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90346-4
更新日期:1992-01-01 00:00:00
abstract::Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid precursor mRNAs and opioid peptides deriving therefrom in inflamed tis...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90509-z
更新日期:1992-01-01 00:00:00
abstract::In adult rats the mystacial vibrissae were clipped on one side of the snout, and the influence of this sensory deprivation on crossed and uncrossed striatal afferents from the substantia nigra, ventral tegmental area, and retrorubral area was examined with the horseradish peroxidase tract tracing technique. Unilateral...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90030-6
更新日期:1992-01-01 00:00:00
abstract::Mature neurons contain two distinct regulated secretory pathways, characterized electron microscopically by so-called large dense core vesicles and small synaptic vesicles, respectively. Each vesicle type is characterized by vesicle-specific proteins, such as the granins (chromogranins/secretogranins) for the matrix o...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90044-3
更新日期:1992-01-01 00:00:00
abstract::Rats received bilateral lesions of the nucleus basalis magnocellularis by infusion of ibotenic acid. Fourteen days later, osmotic minipumps releasing human recombinant nerve growth factor (0.3 micrograms/day) were implanted subcutaneously. Starting one month after the lesion, spatial learning of the animals was tested...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90342-y
更新日期:1992-01-01 00:00:00
abstract::Substance P and calcitonin gene-related peptide (CGRP) are present in nerve fibers innervating the submandibular gland. Radiotherapy of tumors in the head and neck region usually embraces the salivary glands in the irradiated field and consequently a dramatic decrease in salivary function is seen. In this study, the s...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90023-u
更新日期:1992-01-01 00:00:00
abstract::The effects of centrifugal afferents on membrane potentials of identified granule cell layer using evoked field potential profiles, and trans-synaptic activation via antidromic stimulation of output cell axon collaterals. Intracellular recordings maintained for 4-30 min showed complex spontaneous spike discharges and ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90496-o
更新日期:1992-01-01 00:00:00
abstract::The present study utilized an in vitro preparation of the rabbit carotid body, with tissue catecholamine stores labeled by incubation with 3H-tyrosine. The goal was to characterize pharmacologically the voltage-dependent Ca2+ channels present in the type I (glomus) cells of this arterial chemoreceptor organ, and to el...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90260-9
更新日期:1992-01-01 00:00:00
abstract::The distribution and staining pattern of gamma-aminobutyric acid immunoreactivity have been examined by both light and electron microscopy in the dorsal part of the lateral geniculate nucleus of three reptilian species: the turtle Chinemys reevesi, the lizard Ophisaurus apodus and the snake Vipera aspis. After perfusi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90254-y
更新日期:1992-01-01 00:00:00
abstract::Increased levels of preproenkephalin mRNA in spinal cord neurons induced by peripheral tissue inflammation were examined using in situ hybridization histochemistry. In addition, in situ hybridization histochemistry was combined with immunocytochemistry to determine whether increases in preproenkephalin mRNA were co-lo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90144-q
更新日期:1992-01-01 00:00:00
abstract::Antisera raised against protein-glutaraldehyde-amino acid conjugates were used to study the light and electron microscopic distribution of GABA, glutamate, glutamine and taurine in organotypic slice cultures of rat hippocampi. In the stratum oriens and radiatum, glutamate-like immunoreactivity was particularly concent...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90187-7
更新日期:1992-01-01 00:00:00
abstract::In awake, freely moving rats, the intracerebral administration of the excitatory amino acid L-glutamate (30 nmol/0.5 microliters) into discrete regions of the brainstem resulted in a transient and spontaneous pain-like syndrome characterized by an initial vocalization and vigorous escape behavior. Systematic microinje...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90142-o
更新日期:1992-01-01 00:00:00
abstract::The effects of Ricinus toxin on the neurons of the ciliary ganglia were investigated in the quail. The neuronal death and the morphological alterations of the ganglionic cells were assessed following injection of the toxin in the anterior chamber of the eye or after application of the toxin on the postganglionic nerve...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90052-p
更新日期:1991-01-01 00:00:00
abstract::The distributions of the alpha 1-adrenoceptor and its subtypes (alpha 1A and alpha 1B) in human and rat hippocampus are analysed by quantitative receptor autoradiography. alpha 1-Adrenoceptors are labelled by [3H]prazosin. The alpha 1A subtype is visualized by [3H]prazosin after irreversible blockade of alpha 1B adren...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90122-5
更新日期:1991-01-01 00:00:00
abstract::We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90341-k
更新日期:1991-01-01 00:00:00
abstract::The effects of treatment with the antidepressant drug imipramine on neuropeptide Y immunoreactivity were studied immunocytochemically in the rat brain cortex and hypothalamus. It was found that the level of neuropeptide Y immunoreactivity in the cortex was significantly lowered three and 24 h after the last dose of ch...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90366-v
更新日期:1991-01-01 00:00:00
abstract::The roles of acetylcholine and dynorphin (1-13) in the presynaptic control of the release of [3H]dopamine continuously synthesized from [3H]tyrosine were examined in a prominent striosomal enriched area and in an adjacent matrix enriched area of the cat caudate nucleus. This was achieved using microsuperfusion devices...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90340-t
更新日期:1991-01-01 00:00:00
abstract::GABA immunoreactivity was studied in the optic tectum of the frog, Rana esculenta, by postembedding immunohistochemical methods at the light and electron microscopic levels. Nearly one-third of the total population of tectal cells appeared to be GABA-immunoreactive. The proportion of stained neurons was highest in lay...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90051-o
更新日期:1991-01-01 00:00:00
abstract::Following a set of studies concerning the intrinsic electrophysiology of mammalian central neurons in relation to global brain function, we reach the following conclusions: (i) the main difference between wakefulness and paradoxical sleep lies in the weight given to sensory afferents in cognitive images; (ii) otherwis...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/0306-4522(91)90075-y
更新日期:1991-01-01 00:00:00
abstract::Three-dimensional distribution gradients of intracerebrally injected tritiated dopamine were calculated on the basis of concentrations in multiple punch-samples from sequential sections of Macaca fascicularis brain tissue. The monkey was pretreated systemically with a monoamine oxidase inhibitor to retard elimination....
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90107-y
更新日期:1991-01-01 00:00:00
abstract::Microdialysis was combined with a highly sensitive sequential multiple antigen radioimmunoassay to simultaneously measure extracellular cholecystokinin and neurotensin fragments from discrete regions of the rat brain in vivo. The assay was conducted in 96-well plates and provided a limit of detection for both peptides...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90105-w
更新日期:1991-01-01 00:00:00
abstract::The levels of 5-hydroxytryptamine and tachykinin neuropeptides substance P, neurokinin A, neurokinin B and neuropeptide K were measured in the spinal cord of rats treated by intraventricular injection of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine. The spinal cord levels of 5-hydroxytryptamine as mea...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90231-c
更新日期:1991-01-01 00:00:00
abstract::Lipid peroxidation disrupts membrane integrity and causes structural and functional alterations in ischemic tissues. Taurine and ketamine are putative ischemic protectants that affect Ca2+ influx. Here we report the influence of these compounds on lipid peroxidation in subcellular fractions, isolated cells and intact ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90241-f
更新日期:1991-01-01 00:00:00
abstract::This study compared the pharmacology of adrenergic agents that influence plasma extravasation in normal animals with those agents that influence tissue injury in an inflammatory disease model. Specifically we studied the effects of beta 2- and alpha 2-adrenergic receptor agonists and antagonists on bradykinin-induced ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90184-p
更新日期:1991-01-01 00:00:00
abstract::The radioligands [3H]SCH 23390 and [3H]spiroperidol were used to label dopamine D1 and D2 receptors, respectively, in rat brain slices. Striatal sections were incubated in one of various concentrations of radioligand in the presence or absence of (+)-butaclamol and the resulting labeling was determined by liquid scint...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90226-e
更新日期:1991-01-01 00:00:00
abstract::Developmental changes in ganglioside levels and patterns were investigated in neuronal cells dissociated from 17-day-old fetal rat hemispheres for up to 7 days of culture. Increases in ganglioside contents and the onset of GM3 synthesis, which is associated with proliferation of glial cells, were observed as the neuro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90207-5
更新日期:1991-01-01 00:00:00
abstract::The efferent connections of the rostral parvocellular reticular formation to pontine and medullary nuclei in the rat were studied with anterogradely transported Phaseolus vulgaris leucoagglutinin. Dense innervations from the rostral parvocellular reticular formation were found in the mesencephalic trigeminal nucleus, ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90009-d
更新日期:1991-01-01 00:00:00
abstract::Extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. In the presence of phenylephrine (3 microM) to restore the pacemaker activity of otherwise silent serotonergic neurons, superfusion with the 5-hydroxytryptamine1A agonist ipsapirone depressed the firing...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90344-n
更新日期:1991-01-01 00:00:00
abstract::Mast cells are involved in allergic reactions, but may also participate in neurogenic inflammation. The morphology of mast cells in rat dura mater and tongue was evaluated by histochemistry, as well as by scanning and transmission electron microscopy following unilateral trigeminal ganglion stimulation (5 min, 5 Hz, 5...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90253-k
更新日期:1991-01-01 00:00:00
abstract::The effect of systemic administration of domoic acid, a potent structural analogue of kainic acid, on the mouse hippocampus has been studied using light and electron microscopic techniques. Intraperitoneal injections of either domoic acid (4 mg/kg) or kainic acid (32 mg/kg) produced a series of behavioural changes inc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90059-w
更新日期:1991-01-01 00:00:00
abstract::Whole-cell voltage-clamp recordings were made from acutely dissociated neurons obtained from the embryonic chick ciliary ganglion. Recording pipettes were filled with salines containing 120 mM CsCl or 120 mM tetraethylammonium-Cl. Application of depolarizing voltage commands evoked L-type Ca2+ currents and, at voltage...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90086-4
更新日期:1991-01-01 00:00:00
abstract::The localization of glycine receptors in the rat brain was examined by means of in situ hybridization histochemistry using an oligonucleotide probe to the sequence of the alpha 1 subunit. Strongly- or moderately-labeled neurons were found in the cranial nuclei, sensory nuclei such as the spinal trigeminal nucleus, pri...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90302-5
更新日期:1991-01-01 00:00:00
abstract::The topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and lateral portions of the bed nucleus of the stria terminalis and central amygdaloid nucleus was investigated, in the rat, using the retrograde transport of wheat germ agglutinin-conjugated horseradish peroxidase. Alth...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90248-m
更新日期:1991-01-01 00:00:00
abstract::The effects of intrathecal administration of neurokinin A, substance P and [Tyr5, D-Trp6,8,9 Arg10]neurokinin A-(4-10) (Men 10207), a specific NK-2 receptor antagonist, on the spinal nociceptive flexor reflex were studied in decerebrate, spinalized, unanesthetized rats. Intrathecal neurokinin A and substance P facilit...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90071-u
更新日期:1991-01-01 00:00:00
abstract::The effect of exogenously applied cholinergic agents upon mitral-granule cell complex activity of the olfactory bulb was studied in anesthetized rats. Output neurons were activated by electrical paired-pulse stimulation (40-80 ms time interval) applied either to the olfactory nerve (orthodromic stimulation) or to the ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90278-v
更新日期:1991-01-01 00:00:00
abstract::The superior colliculus sends a climbing fiber output to cerebellar vermal lobules VI-VII through the inferior olive. The present study in cats morphologically clarified the existence of a topographical organization in the tecto-olivo-cerebellar projection. A horseradish peroxidase study on the tecto-olivary projectio...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90212-7
更新日期:1991-01-01 00:00:00
abstract::The aim of this study was to examine the development of the basalocortical pathway by using choline acetyltransferase and nerve growth factor receptor immunocytochemistry, acetylcholinesterase histochemistry and retrograde axonal transport. The observations were made in the ferret because in this species brain develop...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90056-t
更新日期:1991-01-01 00:00:00
abstract::The effect of capsaicin on voltage-activated calcium currents was investigated in voltage-clamped somata of cultured adult rat dorsal root ganglion neurons. About half the neurons studied were sensitive to capsaicin, which induced an inward current at negative membrane potentials accompanied by an increase in membrane...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90137-d
更新日期:1991-01-01 00:00:00
abstract::Protein F1/GAP-43 is a protein kinase C substrate associated with axonal growth and synaptic plasticity. We used in situ hybridization in rat brain to determine the cellular distribution of its gene expression. Throughout the septotemporal axis of the adult hippocampus, pyramidal cells express F1/GAP-43 mRNA, but gran...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90284-u
更新日期:1991-01-01 00:00:00
abstract::Sucrose gap techniques recorded dorsal root potentials evoked by supramaximal dorsal root stimulation in in vitro, hemisected frog spinal cords. In 0 mM Mg2+ large (mean 13.0 mV), long lasting (mean 8.1 s) dorsal root potentials were recorded which consisted of two components: (1) an early component sensitive to picro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90200-8
更新日期:1991-01-01 00:00:00